IU honored with National Historic Chemical Landmark for advancing oral health: IU News


From left, Vice President for Research Russell J. Mumper, Executive Dean of the College of Arts and Sciences Rick Van Kooten, Dean of IU ...

From left: Russell J. Mumper, associate dean for research, Rick Van Kooten, executive dean of the College of Arts and Sciences, Carol Anne Murdoch-Kinch, dean of the Indiana University School of Dentistry, Mary K. Carroll, president of the American Chemical Society, Steven L., professor of chemistry, department chair. Tait and IU President Pamela Whitten unveiled the landmark plaque. Photo by Chris Meyer, Indiana University

BLOOMINGTON, Ind.—The invention of stannous fluoride toothpaste marked a turning point in oral health and is a source of pride for Indiana University. Nearly 70 years after IU chemistry and dental researchers pioneered the Crest toothpaste formula, the Indiana University Department of Chemistry was honored as a National Historic Chemistry Landmark by the American Chemical Society on April 4.

The American Chemical Society is one of the world's largest scientific organizations and a leading source of authoritative scientific information. The organization's National Historic Chemistry Landmarks program showcases historical markers that grant landmark status to sites where breakthrough achievements in the chemical sciences occurred.

A permanent plaque from Indiana University will be displayed at the southeast entrance of the Department of Chemistry in the College of Arts and Sciences in Bloomington. Procter & Gamble, the company that commercialized stannous fluoride toothpaste as Crest, received a landmark building for its headquarters in Cincinnati, Ohio.

“The chemicals that created Crest toothpaste in 1955 represent Indiana University’s long track record of transforming research findings into impacting countless lives,” said IU President Pamela Whitten. “This recognition from the American Chemical Society not only serves as a reminder of the outstanding achievements of this university, but also underscores Indiana University’s commitment to multidisciplinary research that addresses society’s most critical needs.”

IU has a long history of working with industry partners to bring research to market. The development of stannous fluoride is just one of the ways the university is using these partnerships to improve lives around the world.

For example, research conducted by chemistry faculty in collaboration with a biotechnology startup led to the creation of injectable glucagon, a hormone that regulates blood sugar. In 1991, researchers at the Indiana University School of Dentistry led the development of DentaShield, a formula licensed to pet product manufacturer Hartz to reduce tartar on dogs' teeth.

How IU innovation is changing dental hygiene

As the Industrial Revolution increased the availability of refined sugar and flour, dental caries, or tooth decay, increased significantly around the world. At this time, the most common method of repairing cavities is tooth extraction. Tooth decay is so common that before fluoride toothpaste was developed, the U.S. Army had to drop its requirement that enlisted soldiers have at least six incisors and six molars because they had trouble finding 18-year-olds who still had 12 missing teeth. There were 32 teeth during World War II.

By the late 1940s, studies showed that people with higher levels of natural fluoride in city drinking water were less susceptible to tooth decay. A team of researchers at Indiana University sought to use this knowledge to create a shelf-stable fluoride ion that is compatible with existing toothpaste formulations.

喬斯夫·穆勒 (Joesph C. Muhler) 遞給他們牙膏和牙刷時,兩個孩子站在他的左右兩側。In 1952, Joseph C. Muhler of the School of Dentistry gave toothpaste and toothbrushes to two of the 12,000 volunteers who participated in a stannous fluoride toothpaste test. Photo courtesy of IU ArchivesJoseph Muhler, a dentist at the Indiana University School of Dentistry, had been searching for ways to prevent tooth decay with Harry G. Day, a professor of chemistry at Indiana University, and discovered that stannous fluoride made tooth enamel stronger than any other The combination of compounds is more resistant to acids. Muhler presented their findings at a dental conference, where they caught the attention of Verling M. Votaw, a graduate of the Indiana University School of Dentistry and director of product research for Procter & Gamble.

Procter & Gamble funded their research with the hope of producing and distributing the final product once discovered. A year later, Mueller and Day began working with Indiana University chemistry professor William Nyberger, who had found a way to deliver fluoride ions into toothpaste.

In 1952, clinical trials began in the community of Bloomington. More than 12,000 adults and children have demonstrated the effectiveness of this toothpaste formula in preventing cavities. Research shows that using stannous fluoride toothpaste reduces the number of cavities by 30% compared to a control group. In 1956, toothpaste was selling nationwide; by 1960, the American Dental Association issued Crest its first seal of approval.

IU patented the discovery, which was later licensed to Procter & Gamble. The university received royalties from the patent until the patent expired in 1975, with part of the funds used to establish the Institute of Oral Health in the School of Dentistry in 1968. laboratory.

Media Kit: Access Film and Photos of Recognition Ceremony

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“This outstanding recognition demonstrates how academic-industry partnerships drive research innovation within the College and across IU, leading to discoveries that positively impact millions of people. In fact, IU chemistry professors at the time were Departmental work laid the foundation for a collaboration with the Indiana University School of Dentistry, which in turn led to the commercialization of Procter & Gamble's Crest toothpaste, transforming oral hygiene and global public health — Rick Van Kutenexecutive dean of the College of Arts and Sciences

“Some health care innovations are so compelling, so effective, and so widely adopted that those who live after their development have a hard time imagining what the world was like before they existed. The stannous fluoride toothpaste developed at Indiana University is just that. One such innovation. With the introduction of stannous fluoride toothpaste, tooth decay prevalence dropped by more than 75%. Today, researchers and clinicians at the School of Dentistry and the Institute of Oral Health continue to innovate new treatments and test new products to benefit all. Oral care. From new formulations of toothpaste and mouthwash to developing a cavity-fighting gum that can be used when brushing isn’t possible, we’re proud to build on Indiana University’s history of innovation — Carol Anne Murdoch-KinchDean, Indiana University School of Dentistry

“It’s amazing to think about the impact IU students and faculty have had on improving the lives of billions of people around the world. More than 70 years ago, research in the Department of Chemistry led to huge advances in oral health around the world. Today, this The tradition lives on in current research in chemistry that impacts human health, energy, materials, medicine, information and measurement sciences. Indiana University students, scientists and faculty contribute to advancing knowledge and technology that benefits our world. society. – Steven TateHerman T. Briscoe Professor of Chemistry and Chair of the Chemistry Department in the College of Arts and Sciences

“The collaborative development of stannous fluoride, the basis of Crest toothpaste, is a lasting testament to the power of institutions that share a mission to harness the highest quality science for the benefit of society. This landmark award was awarded yesterday at Procter & Gamble and now at Indiana University The honor makes us very proud and provides inspiration as we continue to work hard to bring irresistibly high-quality products to the market — Gerald BaileySenior Vice President of Corporate Research and Development at Procter & Gamble

Since its introduction, fluoride toothpaste has improved the dental health of millions of people around the world by delivering powerful cavity-fighting chemicals to consumers, a legacy that is worthy of pride. We are pleased to honor Indiana University and P&G The company’s transformative work, which affirms the power of academic-industry partnerships — mary k carrollPresident of the American Chemical Society and Indiana University alumnus



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