Effects of mouthwash on periodontal pathogens and glycemic control in patients with type 2 diabetes mellitus


  • Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C. & Kent, R. L. Microbial complexes in subgingival plaque. J. Clin. Periodontol. 25, 134–144 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Socransky, S. S. & Haffaiee, A. D. Dental biofilms: Difficult therapeutic targets. Periodontology 2000(28), 12–55 (2002).

    Article 

    Google Scholar 

  • Kwon, T. H., Lamster, I. B. & Levin, L. Current concepts in the management of periodontitis. Int. Dent. J. 71, 462–476 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Haffajee, A. D. & Socransky, S. S. Microbial etiological agents of destructive periodontal diseases. Periodontology 2000(5), 78–111 (1994).

    Article 

    Google Scholar 

  • Ji, S., Choi, Y. S. & Choi, Y. Bacterial invasion and persistence: Critical events in the pathogenesis of periodontitis?. J. Periodontal. Res. 50, 570–585 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Saito, A. et al. Assessment of oral self-care in patients with periodontitis: A pilot study in a dental school clinic in Japan. BMC Oral Health 29, 27 (2009).

    Article 

    Google Scholar 

  • van der Maarel-Wierink, C. D., Vanobbergen, J. N. O., Bronkhorst, E. M., Schols, J. M. G. A. & de Baat, C. Oral health care and aspiration pneumonia in frail older people: A systematic literature review. Gerodontology 30, 3–9 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Field, E. A., Nind, D., Varga, E. & Martin, M. V. The effect of chlorhexidine irrigation on the incidence of dry socket: A pilot study. Br. J. Oral. Maxillofac. Surg. 26, 395–401 (1998).

    Article 

    Google Scholar 

  • Nomura, R. et al. Inhibitory effect of a mouth rinse formulated with chlorhexidine gluconate, ethanol, and green tea extract against major oral bacterial species. J. Oral Sci. 62, 206–211 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bourgeois, D., Gonçalves, L. S., Lima-Jounior, J. C. & Carrouel, F. Editorial: The oral microbiome is a key factor in oral and systemic health. Front. Microbiol. 13, 855668 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gare, J. et al. Periodontal conditions and pathogens associated with pre-eclampsia: A scoping review. Int. J. Environ. Res. Public Health 18, 7194 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Isola, G. et al. Periodontal health and disease in the context of systemic diseases. Mediators Inframm. 2023, 9720947 (2023).

    Google Scholar 

  • Sanz, M. et al. Periodontitis and cardiovascular diseases: Consensus report. J. Clin. Periodontol. 47, 268–288 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mealey, B. L. & Oates, T. W. American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J. Periodontol. 77, 1289–1303 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Novak, M. J., Potter, R. M., Blodgett, J. & Ebersole, J. L. Periodontal disease in Hispanic Americans with type-2 diabetes. J. Periodontol. 79, 629–636 (2008).

    Article 
    PubMed 

    Google Scholar 

  • Jimenez, M., Hu, F. B., Marino, M., Li, Y. & Joshipura, K. J. Type 2 diabetes mellitus and 20 year incidence of periodontitis and tooth loss. Diabetes Res. Clin. Pract. 98, 494–500 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Borgnakke, W. S., Ylöstalo, P. V., Taylor, G. W. & Genco, R. J. Effect of periodontal disease on diabetes: Systematic review of epidemiologic observational evidence. J. Clin. Periodontol. 40, S135-152 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Chapple, I. L., Genco, R., Working group 2 of joint EFP/AAP workshop. Working group 2 of joint EFP/AAP workshop Diabetes and periodontal diseases: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J. Periodontol. 84, S106-112 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Nascimento, G. G., Leite, F. R. M., Vestergaard, P., Scheutz, F. & López, R. Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies. Acta Diabetol. 55, 653–667 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Eke, P. I. et al. Risk indicators for periodontitis in US adults: NHANES 2009 to 2012. J. Periodontol. 87, 1174–1185 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Harreiter, J. & Roden, M. Diabetes mellitus—Definition, classification, diagnosis, screening and prevention (update 2019). Wien. Klin. Wochenschr. 131, 6–15 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Munenaga, Y., Hiroshima Study Group, Yamashina, T., Tanaka, J. & Nishimura, F. Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics: Results from the Hiroshima Study. Diabetes Res. Clin. Pract. 100, 53–60 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Figueiredo, L. C. et al. Full-mouth scaling and root planing in type 2 diabetic subjects: One-year microbiological outcomes. Aust. Dent. J. 59, 490–496 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • D’Aiuto, F. et al. Systemic effects of periodontitis treatment in patients with type 2 diabetes: A 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol. 6, 954–965 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Mauri-Obradors, E. et al. Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial. J. Clin. Periodontol. 45, 345–353 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Aemaimanan, P., Amimanan, P. & Taweechaisupapong, S. Quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. Anaerobe 22, 64–68 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Higgins, T. et al. Seasonal variation in hemoglobin A1c: Is it the same in both hemispheres?. J. Diabetes Sci. Technol. 3, 668–671 (2009).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sakura, H., Tanaka, Y. & Iwamoto, Y. Seasonal fluctuations of glycated hemoglobin levels in Japanese diabetic patients. Diabetes Res. Clin. Pract. 88, 65–70 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Galicia-Garcia, U. et al. Pathophysiology of type 2 diabetes mellitus. Int. J. Mol. Sci. 21, 6275 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Damanik, J. & Yunir, E. Type 2 diabetes mellitus and cognitive impairment. Acta Med. Indones. 53, 213–220 (2021).

    PubMed 

    Google Scholar 

  • Zheng, Y., Ley, S. H. & Hu, F. B. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat. Rev. Endocrinol. 14, 88–98 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Faselis, C. et al. Microvascular complications of type 2 diabetes mellitus. Curr. Vasc. Pharmacol. 18, 117–124 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Taylor, G. W., Burt, B. A., Becker, M. P. & Genco, R. J. Glycemic control and alveolar bone loss progression in type 2 diabetes. Ann. Periodontol. 3, 30–39 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Luong, A. B. et al. Periodontitis and diabetes mellitus co-morbidity: A molecular dialogue. J. Oral Biosci. 63, 360–369 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nelson, R. G. et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care 13, 836–840 (1990).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tanaka, T. & Horie, T. Development of an in vitro biofilm formation model for screening anti-periodontal disease agents. Am. J. Dent. 35, 323–328 (2022).

    PubMed 

    Google Scholar 

  • Lang, N. P., Schild, U. & Brägger, U. Effect of chlorhexidine (0.12%) rinses on periodontal tissue healing after tooth extraction. (I). Clinical parameters. J. Clin. Periodontol. 21, 415–421 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Maruniak, J. et al. The effect of 3 mouthrinses on plaque and gingivitis development. J. Clin. Periodontol. 19, 19–23 (1992).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bellary, S., Kyrou, I., Brown, J. E. & Bailey, C. J. Type 2 diabetes mellitus in older adults: clinical considerations and management. Nat. Rev. Endocrinol. 17, 534–548 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Halim, M. & Halim, A. The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes). Diabetes Metab. Syndr. 13, 1165–1172 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Ciarambino, T. et al. Influence of gender in diabetes mellitus and its complication. Int. J. Mol. Sci. 23, 8850 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kautzky-Willer, A., Harreiter, J. & Pacini, G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocr. Rev. 37, 278–316 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ozawa, H. et al. Maximum body mass index before onset of type 2 diabetes is independently associated with advanced diabetic complications. BMJ Open Diabetes Res. Care 9, e002466 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fransson, C., Berglundh, T. & Lindhe, J. The effect of age on the development of gingivitis. Clinical, microbiological and histological findings. J. Clin. Periodontol. 23, 379–385 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Fransson, C., Mooney, J., Kinane, D. F. & Berglundh, T. Differences in the inflammatory response in young and old human subjects during the course of experimental gingivitis. J. Clin. Periodontol. 26, 453–460 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Holm-Pedersen, P., Agerbaek, N. & Theilade, E. Experimental gingivitis in young and elderly individuals. J. Clin. Periodontol. 26, 14–24 (1975).

    Article 

    Google Scholar 

  • Benn, A. M. L. et al. Associations of sex, oral hygiene and smoking with oral species in distinct habitats at age 32 years. Eur. J. Oral Sci. 130, e12829 (2022).

    Article 
    PubMed 

    Google Scholar 

  • ElSayed, N. A. et al. 2. Classification and diagnosis of diabetes: Standards of care in diabetes—2023. Diabetes Care 46, S19–S40 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Yamasaki, Y. et al. Distribution of periodontopathic bacterial species in dogs and their owners. Arch. Oral. Biol. 57, 1183–1188 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nomura, R. et al. Distribution of periodontopathic bacterial species between saliva and tonsils. Odontology 111, 719–727 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Kato, Y. et al. Molecular detection of human periodontal pathogens in oral swab specimens from dogs in Japan. J. Vet. Dent. 28, 84–89 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Watanabe, K. & Frommel, T. O. Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Treponema denticola detection in oral plaque samples using the polymerase chain reaction. J. Clin. Periodontol. 23, 212–219 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ashimoto, A., Chen, C., Bakker, I. & Slots, J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol. Immunol. 11, 266–273 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Conrads, G. et al. PCR reaction and dot-blot hybridization to monitor the distribution of oral pathogens within plaque samples of periodontally healthy individuals. J. Periodontol. 67, 994–1003 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kuboniwa, M. et al. Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes. Oral Microbiol. Immunol. 19, 168–176 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Faul, F., Erdfelder, E., Lang, A.-G. & Buchner, A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175–191 (2007).

    Article 
    PubMed 

    Google Scholar 



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